Technology

Overview

CombiPhos Catalysts were derived from novel combinatorial technologies, and used for a variety of cross-coupling reactions. So far, over 300 pharmaceutical companies over the world apply these catalysts in the drug discovery and processes. Among these pharmaceutical companies are Merck, Pfizer, Aventis, AstraZeneca, Norvatis, BMS, Schering-Plough, Abbott Laboratories, Johnson & Johnson, GSK, Amgen, and Roche.

Four Advantages of CombiPhos' Cross-Coupling Catalysts

1. Air- and Moisture-Stability (can be stored in air for many years, and use H2O as a solvent!).

2. Very High Activity [about 100 times higher than other catalysts (e.g. Pd(PPh3)4, PdCl2(dppf) etc !).

3. Catalyst Residue can be easily removed (residue is an ionic complex which is less soluble in organic solvents !).

4. Catalyst is recyclable (can be re-used for many times !)